Helena I.M. Boshoff : rechercher sur Z-Library

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Articles (129)
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1

Structure−Activity Relationships of Antitubercular Nitroimidazoles. 1. Structural Features Associated with Aerobic and Anaerobic Activities of 4- and 5-Nitroimidazoles

Kim, Pilho, Zhang, Liang, Manjunatha, Ujjini H., Singh, Ramandeep, Patel, Sejal, Jiricek, Jan, Keller, Thomas H., Boshoff, Helena I., Barry, Clifton E., Dowd, Cynthia S.

Journal:

Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 275 KB

english, 2009

2

Some Nigerian anti-tuberculosis ethnomedicines: A preliminary efficacy assessment

Ibekwe, Nneka N., Nvau, John B., Oladosu, Peters O., Usman, Auwal M., Ibrahim, Kolo, Boshoff, Helena I., Dowd, Cynthia S., Orisadipe, Abayomi T., Aiyelaagbe, Olapeju, Adesomoju, Akinbo A., Barry, Clif

Journal:

Journal of Ethnopharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 882 KB

english, 2014

3

The mechanism of action of PA-824

Manjunatha, Ujjini, Boshoff, Helena I.M., Barry, Clifton E.

Journal:

Communicative & Integrative Biology

Année:

2009

Langue:

english

Fichier:

PDF, 1.22 MB

english, 2009

4

Design, synthesis, and evaluation of substituted nicotinamide adenine dinucleotide (NAD + ) synthetase inhibitors as potential antitubercular agents

Wang, Xu, Ahn, Yong-Mo, Lentscher, Adam G., Lister, Julia S., Brothers, Robert C., Kneen, Malea M., Gerratana, Barbara, Boshoff, Helena I., Dowd, Cynthia S.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 654 KB

english, 2017

5

The present state of the tuberculosis drug development pipeline

J Libardo, M Daben, Boshoff, Helena IM, Barry, Clifton E

Journal:

Current Opinion in Pharmacology

Année:

2018

Langue:

english

Fichier:

PDF, 2.08 MB

english, 2018

6

Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design

Dong, Yin Yao, Wang, Hua, Pike, Ashley C.W., Cochrane, Stephen A., Hamedzadeh, Sadra, Wyszyński, Filip J., Bushell, Simon R., Royer, Sylvain F., Widdick, David A., Sajid, Andaleeb, Boshoff, Helena I.,

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 8.70 MB

english, 2018

7

Targeting of fumarate hydratase from Mycobacterium tuberculosis using allosteric inhibitors with a dimeric-binding mode

Whitehouse, Andrew J, Libardo, M. Daben J., Kasbekar, Monica, Brear, Paul D, Fischer, Gerhard, Thomas, Craig J, Barry, Cliff, Boshoff, Helena I. M., Coyne, Anthony G, Abell, Chris

Journal:

Journal of Medicinal Chemistry

Année:

2019

Langue:

english

Fichier:

PDF, 2.89 MB

english, 2019

8

Design, Synthesis, Biological Evaluation and Molecular Dynamic Simulation Studies of Diphenyl Ether Derivatives as Antitubercular and Antibacterial Agents

Khade, Amol B., Eshwara, Vandana K., Boshoff, Helena I.M., Arora, Kriti, Tiwari, Ashutosh, Bhat, Pritesh, Tiwari, Mradul, Shenoy, G. Gautham

Journal:

ChemistrySelect

Année:

2020

Langue:

english

Fichier:

PDF, 2.06 MB

english, 2020

9

PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis

Wang, Qinglan, Boshoff, Helena I. M., Harrison, Justin R., Ray, Peter C., Green, Simon R., Wyatt, Paul G., Barry, Clifton E.

Journal:

Année:

2020

Fichier:

PDF, 714 KB

2020

10

ChemInform Abstract: The Effect of 5-Substitution on the Electrochemical Behavior and Antitubercular Activity of PA-824.

Soledad Bollo, Luis J. Nunez-Vergara, Sunhee Kang, Liang Zhang, Helena I. Boshoff, Clifton E. III Barry, Juan A. Squella, Cynthia S. Dowd

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 27 KB

english, 2011

11

The effect of 5-substitution on the electrochemical behavior and antitubercular activity of PA-824

Soledad Bollo, Luis J. Núñez-Vergara, Sunhee Kang, Liang Zhang, Helena I. Boshoff, Clifton E. Barry III, Juan A. Squella, Cynthia S. Dowd

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 687 KB

english, 2011

12

The impact of genomics on discovering drugs against infectious diseases

Helena I.M. Boshoff, Ujjini H. Manjunatha

Journal:

Microbes and Infection

Année:

2006

Langue:

english

Fichier:

PDF, 245 KB

english, 2006

13

Natural product inhibitors of fatty acid biosynthesis: synthesis of the marine microbial metabolites pseudopyronines A and B and evaluation of their anti-infective activities

Anna C. Giddens, Lone Nielsen, Helena I. Boshoff, Deniz Tasdemir, Remo Perozzo, Marcel Kaiser, Feng Wang, James C. Sacchettini, Brent R. Copp

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 274 KB

english, 2008

14

Antimycobacterial natural products: synthesis and preliminary biological evaluation of the oxazole-containing alkaloid texaline

Anna C. Giddens, Helena I.M. Boshoff, Scott G. Franzblau, Clifton E. Barry III, Brent R. Copp

Journal:

Tetrahedron Letters

Année:

2005

Langue:

english

Fichier:

PDF, 105 KB

english, 2005

15

Top down characterization of secreted proteins fromMycobacterium tuberculosisby electron capture dissociation mass spectrometry

Ying Ge, Mariam ElNaggar, Siu Kwan Sze, Han Bin Oh, Tadhg P Begley, Fred W McLafferty, Helena Boshoff, Clifton E Barry III

Journal:

Journal of the American Society for Mass Spectrometry

Année:

2003

Langue:

english

Fichier:

PDF, 668 KB

english, 2003

16

Quantification of small molecule organic acids from Mycobacterium tuberculosis culture supernatant using ion exclusion liquid chromatography/mass spectrometry

Michael B. Goodwin, Helena I. Boshoff, Clifton E. Barry 3rd, Cynthia S. Dowd

Journal:

Rapid Communications in Mass Spectrometry

Année:

2006

Langue:

english

Fichier:

PDF, 227 KB

english, 2006

17

Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles

Meera Gurumurthy, Tathagata Mukherjee, Cynthia S. Dowd, Ramandeep Singh, Pornwaratt Niyomrattanakit, Jo Ann Tay, Amit Nayyar, Yong Sok Lee, Joseph Cherian, Helena I. Boshoff, Thomas Dick, Clifton E. B

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 957 KB

english, 2012

18

Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis

Backus, Keriann M, Boshoff, Helena I, Barry, Conor S, Boutureira, Omar, Patel, Mitul K, D'Hooge, François, Lee, Seung Seo, Via, Laura E, Tahlan, Kapil, Barry, Clifton E

Journal:

Nature Chemical Biology

Année:

2011

Langue:

english

Fichier:

PDF, 973 KB

english, 2011

19

Getting the iron out

Barry, Clifton E., Boshoff, Helena

Journal:

Nature Chemical Biology

Année:

2005

Langue:

english

Fichier:

PDF, 126 KB

english, 2005

20

Tuberculosis — metabolism and respiration in the absence of growth

Boshoff, Helena I. M., Barry, Clifton E.

Journal:

Nature Reviews Microbiology

Année:

2005

Langue:

english

Fichier:

PDF, 319 KB

english, 2005

21

Spectrum of latent tuberculosis — existing tests cannot resolve the underlying phenotypes: author's reply

Barry, Clifton E., Boshoff, Helena I., Dartois, Véronique, Dick, Thomas, Ehrt, Sabine, Flynn, JoAnne, Schnappinger, Dirk, Wilkinson, Robert J., Young, Douglas

Journal:

Nature Reviews Microbiology

Année:

2010

Langue:

english

Fichier:

PDF, 129 KB

english, 2010

22

The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

Barry, Clifton E., Boshoff, Helena I., Dartois, Véronique, Dick, Thomas, Ehrt, Sabine, Flynn, JoAnne, Schnappinger, Dirk, Wilkinson, Robert J., Young, Douglas

Journal:

Nature Reviews Microbiology

Année:

2009

Langue:

english

Fichier:

PDF, 870 KB

english, 2009

23

Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity

Moraski, Garrett C., Markley, Lowell D., Hipskind, Philip A., Boshoff, Helena, Cho, Sanghyun, Franzblau, Scott G., Miller, Marvin J.

Journal:

ACS Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 971 KB

english, 2011

24

Development of a Selective Activity-Based Probe for Adenylating Enzymes: Profiling MbtA Involved in Siderophore Biosynthesis from Mycobacterium tuberculosis

Duckworth, Benjamin P., Wilson, Daniel J., Nelson, Kathryn M., Boshoff, Helena I., Barry, Clifton E., Aldrich, Courtney C.

Journal:

ACS Chemical Biology

Année:

2012

Langue:

english

Fichier:

PDF, 2.39 MB

english, 2012

25

C4-Alkylthiols with activity against Moraxella catarrhalis and Mycobacterium tuberculosis

Maya B. Kostova, Carey J. Myers, Tim N. Beck, Balbina J. Plotkin, Jacalyn M. Green, Helena I.M. Boshoff, Clifton E. Barry III, Jeffrey R. Deschamps, Monika I. Konaklieva

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 683 KB

english, 2011

26

Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers

Stephen T. McCracken, Marcel Kaiser, Helena I. Boshoff, Peter D.W. Boyd, Brent R. Copp

Journal:

Bioorganic & Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 1.51 MB

english, 2012

27

Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds

Garrett C. Moraski, Lowell D. Markley, Mayland Chang, Sanghyun Cho, Scott G. Franzblau, Chang Hwa Hwang, Helena Boshoff, Marvin J. Miller

Journal:

Bioorganic & Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 584 KB

english, 2012

28

Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs

Eugene Uh, Emily R. Jackson, Géraldine San Jose, Marcus Maddox, Robin E. Lee, Richard E. Lee, Helena I. Boshoff, Cynthia S. Dowd

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 508 KB

english, 2011

29

Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis

Benjamin P. Duckworth, Todd W. Geders, Divya Tiwari, Helena I. Boshoff, Paul A. Sibbald, Clifton E. Barry III, Dirk Schnappinger, Barry C. Finzel, Courtney C. Aldrich

Journal:

Chemistry & Biology

Année:

2011

Langue:

english

Fichier:

PDF, 519 KB

english, 2011

30

Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824

Susan E. Cellitti, Jennifer Shaffer, David H. Jones, Tathagata Mukherjee, Meera Gurumurthy, Badry Bursulaya, Helena I. Boshoff, Inhee Choi, Amit Nayyar, Yong Sok Lee, Joseph Cherian, Pornwaratt Niyomr

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2012

31

The Mycobacterium tuberculosis β-oxidation genes echA5 and fadB3 are dispensable for growth in vitro and in vivo

Kerstin J. Williams, Helena I. Boshoff, Nitya Krishnan, Jacqueline Gonzales, Dirk Schnappinger, Brian D. Robertson

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 776 KB

english, 2011

32

Structure–Activity Relationships of Antitubercular Nitroimidazoles. 3. Exploration of the Linker and Lipophilic Tail of ((S)-2-Nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-Amino PA-824).

Cherian, Joseph, Choi, Inhee, Nayyar, Amit, Manjunatha, Ujjini H., Mukherjee, Tathagata, Lee, Yong Sok, Boshoff, Helena I., Singh, Ramandeep, Ha, Young Hwan, Goodwin, Michael

Journal:

Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.33 MB

english, 2011

33

Nitroimidazoles for the treatment of TB: past, present and future

Mukherjee, Tathagata, Boshoff, Helena

Journal:

Future Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.94 MB

english, 2011

34

DnaE2 Polymerase Contributes to In Vivo Survival and the Emergence of Drug Resistance in Mycobacterium tuberculosis

Helena I.M. Boshoff, Michael B. Reed, Clifton E. Barry III, Valerie Mizrahi

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 133 KB

english, 2003

35

Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis

Pradeep Kumar, Kriti Arora, John R. Lloyd, Ill Y. Lee, Vinod Nair, Elizabeth Fischer, Helena I. M. Boshoff, Clifton E. Barry III

Journal:

Molecular Microbiology

Année:

2012

Langue:

english

Fichier:

PDF, 973 KB

english, 2012

36

5‘- O -[( N -Acyl)sulfamoyl]adenosines as Antitubercular Agents that Inhibit MbtA: An Adenylation Enzyme Required for Siderophore Biosynthesis of the Mycobactins

Qiao, Chunhua, Gupte, Amol, Boshoff, Helena I., Wilson, Daniel J., Bennett, Eric M., Somu, Ravindranadh V., Barry, Clifton E., Aldrich, Courtney C.

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 350 KB

english, 2007

37

Pathway-Selective Sensitization of Mycobacterium tuberculosis for Target-Based Whole-Cell Screening

Garth L. Abrahams, Anuradha Kumar, Suzana Savvi, Alvin W. Hung, Shijun Wen, Chris Abell, Clifton E. Barry III, David R. Sherman, Helena I.M. Boshoff, Valerie Mizrahi

Journal:

Chemistry & Biology

Année:

2012

Langue:

english

Fichier:

PDF, 2.23 MB

english, 2012

38

Structure–activity relationships of antitubercular salicylanilides consistent with disruption of the proton gradient via proton shuttling

Ill-Young Lee, Todd D. Gruber, Amanda Samuels, Minhan Yun, Bora Nam, Minseo Kang, Kathryn Crowley, Benjamin Winterroth, Helena I. Boshoff, Clifton E. Barry III

Journal:

Bioorganic & Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 633 KB

english, 2013

39

Is the mycobacterial cell wall a hopeless drug target for latent tuberculosis?

Helena I. Boshoff, Clifton E. Barry III

Journal:

Drug Discovery Today: Disease Mechanisms

Année:

2006

Langue:

english

Fichier:

PDF, 269 KB

english, 2006

40

Mechanisms underlying mycobacterial infections

Helena I Boshoff, Kapil Tahlan

Journal:

Drug Discovery Today: Disease Mechanisms

Année:

2010

Langue:

english

Fichier:

PDF, 80 KB

english, 2010

41

Systems biology approaches to understanding mycobacterial survival mechanisms

Helena I.M. Boshoff, Desmond S. Lun

Journal:

Drug Discovery Today: Disease Mechanisms

Année:

2010

Langue:

english

Fichier:

PDF, 225 KB

english, 2010

42

Bioactive Pyridine- N -oxide Disulfides from Allium stipitatum ¶

O’Donnell, Gemma, Poeschl, Rosemarie, Zimhony, Oren, Gunaratnam, Mekala, Moreira, Joao B. C., Neidle, Stephen, Evangelopoulos, Dimitrios, Bhakta, Sanjib, Malkinson, John P., Boshoff, Helena I., Lenaer

Journal:

Journal of Natural Products

Année:

2009

Langue:

english

Fichier:

PDF, 242 KB

english, 2009

43

Inhibition of Siderophore Biosynthesis by 2-Triazole Substituted Analogues of 5′- O -[ N -(Salicyl)sulfamoyl]adenosine: Antibacterial Nucleosides Effective against Mycobacterium tuberculosis

Gupte, Amol, Boshoff, Helena I., Wilson, Daniel J., Neres, João, Labello, Nicholas P., Somu, Ravindranadh V., Xing, Chengguo, Barry, Clifton E., Aldrich, Courtney C.

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 1.44 MB

english, 2008

44

Advancement of Imidazo[1,2- a ]pyridines with Improved Pharmacokinetics and nM Activity vs. Mycobacterium tuberculosis

Moraski, Garrett C., Markley, Lowell D., Cramer, Jeffrey, Hipskind, Philip A., Boshoff, Helena, Bailey, Mai A., Alling, Torey, Ollinger, Juliane, Parish, Tanya, Miller, Marvin J.

Journal:

ACS Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 349 KB

english, 2013

45

[Progress in Drug Research] Systems Biological Approaches in Infectious Diseases Volume 64 || Metabolic control analysis to identify optimal drug targets

Boshoff, Helena I., Barry, Clifton E.

Année:

2007

Langue:

english

Fichier:

PDF, 200 KB

english, 2007

46

A novel F 420 -dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents

Gurumurthy, Meera, Rao, Martin, Mukherjee, Tathagata, Rao, Srinivasa P. S., Boshoff, Helena I., Dick, Thomas, Barry, Clifton E., Manjunatha, Ujjini H.

Journal:

Molecular Microbiology

Année:

2013

Langue:

english

Fichier:

PDF, 924 KB

english, 2013

47

Non-Nucleoside Inhibitors of BasE, an Adenylating Enzyme in the Siderophore Biosynthetic Pathway of the Opportunistic Pathogen Acinetobacter baumannii

Neres, João, Engelhart, Curtis A., Drake, Eric J., Wilson, Daniel J., Fu, Peng, Boshoff, Helena I., Barry, Clifton E., Gulick, Andrew M., Aldrich, Courtney C.

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 2.12 MB

english, 2013

48

Rationally Designed Nucleoside Antibiotics That Inhibit Siderophore Biosynthesis of Mycobacterium t uberculosis

Somu, Ravindranadh V., Boshoff, Helena, Qiao, Chunhua, Bennett, Eric M., Barry, Clifton E., Aldrich, Courtney C.

Journal:

Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 118 KB

english, 2006

49

[Progress in Drug Research] Systems Biological Approaches in Infectious Diseases Volume 64 || Toward whole cell modeling and simulation: Comprehensive functional genomics through the constraint-based approach

Boshoff, Helena I., Barry, Clifton E.

Année:

2007

Langue:

english

Fichier:

PDF, 871 KB

english, 2007

50

Structure–activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis

Meissner, Anja, Boshoff, Helena I., Vasan, Mahalakshmi, Duckworth, Benjamin P., Barry, Clifton E., Aldrich, Courtney C.

Journal:

Bioorganic & Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 756 KB

english, 2013